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pentobarbital will reduce the level or outcome of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will reduce the level or outcome of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unidentified.pentobarbital will decrease the extent or result of levoketoconazole by